Análisis de variabilidad del ritmo cardiaco y su relaicón con la sensibilidad insulínica en pacientes obesos y con sobrepesos.

Autores/as

  • Alexis Espinoza-Salinas Universidad Santo Tomás
  • Edson Zafra-Santos Universidad Santo Tomás
  • Gustavo Pavez-Von Martens Universidad Santo Tomás
  • Cristian Cofré-Bolados Universidad Santo Tomás
  • Jorge Lemus-Zúñiga Universidad Santo Tomás
  • Pablo Sánchez-Aguilera Universidad Santo Tomás

Palabras clave:

Autonomic nervous system, Heart rate, Insulin resistance, Obesity, Overweight

Resumen

Background: Heart rate variability analysis provides quantitative information about vagal and sympathetic modulation of cardiac function. Aim: To analyze the relationship between heart rate variability and insulin resistance in obese patients. Material and methods: Male participants were studied, divided in 10 obese subjects aged 27 ± 2 years with a body mass index (BMI) of 31.2 ± 1.3 kg/m2, 15 overweight subjects aged 24 ± 3 years with a BMI of 26.7 ± 1.5 kg/m2 and 14 normal weight subjects aged 21 ± 2 years with a BMI of 22.5 ± 1.3 kg/m2. Resting heart rate variability was measured in a period of 5 minutes. A spectral analysis was done measuring the low frequency/high frequency ratio (LF/HF). A non- linear analysis was carried out measuring the standard deviation of the instantaneous variation of RR intervals (SD1) and ?-1 or a fractal analysis of RR interval complexity. A fasting blood sample was obtained to measure blood glucose and insulin and calculate the homeostasis model assessment for insulin resistance (HOMA-IR). Results: Among obese subjects HOMA-IR, LF/HF, ?-1 and SD1 values were 2.6 ± 2.1, 2.4 ± 1.8, 1.2 ± 0.06 and 22.5 ± 10 respectively. The figures for normal weight subjects were 0.5 ± 0.1, 1.3 ± 0.2, 0.9 ± 0.3 and 26 ± 7.8 respectively. Conclusions: There is an association between spectral and fractal values of heart rate variability and HOMA-IR. These results may indicate a predominance of sympathetic control of heart rate among obese subjects.

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Publicado

2015-08-20

Cómo citar

Espinoza-Salinas, A., Zafra-Santos, E., Pavez-Von Martens, G., Cofré-Bolados, C., Lemus-Zúñiga, J., & Sánchez-Aguilera, P. (2015). Análisis de variabilidad del ritmo cardiaco y su relaicón con la sensibilidad insulínica en pacientes obesos y con sobrepesos. Revista Médica De Chile, 143(9). Recuperado a partir de https://mail.revistamedicadechile.cl/index.php/rmedica/article/view/3942

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