Sensibilidad diagnóstica en gammapatías monoclonales y utilidad de las cadenas livianas libres en suero: realidad en un hospital público chileno.

Resumen

Background: International guidelines suggest a screening panel for monoclonal gammopathies that contains serum protein electrophoresis (SPE), free light chain (FLC) measurements and immunofixation. This combination provides the possibility of a timely accurate diagnosis. Aim: To evaluate the sensibility of a simple screening panel (SPE + FLC). Material and methods: We analyzed 75 serum samples of patients with a monoclonal gammopathy. Results: The sensitivity and specificity of the combination of SPE + FLC for the diagnosis of monoclonal gammopathy were 95% (95% confidence intervals 89-99) and 99% (95% confidence intervals 96-100), respectively. Conclusions: We were able to validate the international recommendations about the diagnostic accuracy of this simple combination of two tests in serum for monoclonal gammopathy.